Harrison’s Principles of Internal Medicine 20th Edition 2 Vols

Introducing the Landmark Twentieth Edition of the Global Icon of Internal Medicine.

The definitive guide to internal medicine is more essential than ever with the latest in disease mechanisms, updated clinical trial results and recommended guidelines, state-of-the art radiographic images, therapeutic approaches and specific treatments, hundreds of demonstrative full-color drawings, and practical clinical decision trees and algorithms.

Recognized by healthcare professionals worldwide as the leading authority on applied pathophysiology and clinical medicine, Harrison’s Principles of Internal Medicine gives you the informational foundation you need to provide the best patient care possible.

Essential for practice and education, the landmark 20th Edition features:

• Thoroughly revised content—covering the many new breakthroughs and advances in clinical medicine that have occurred since the last edition of Harrison’s. Chapters on acute and chronic hepatitis, management of diabetes, immune-based therapies in cancer, multiple sclerosis, cardiovascular disease, HIV, and many more, deliver the very latest information on disease mechanisms, diagnostic options, and the specific treatment guidance you need to provide optimal patient care.
• State-of-the-art coverage of disease mechanisms: Harrison’s focuses on pathophysiology with rigor, and with the goal of linking disease mechanisms to treatments. Improved understanding of how diseases develop and progress not only promotes better decision-making and higher value care, but also makes for fascinating reading and improved retention. Harrison’s summarizes important new basic science developments, such as the role of mitochondria in programmed and necrotic cell death, the immune system’s role in cancer development and treatment, the impact of telomere shortening in the aging and disease processes, and the role of the microbiome in health and disease. Understanding the role of inflammation in cardiovascular disease, the precise mechanisms of immune deficiency in HIV/AIDS, prions and misfolded proteins in neurodegenerative diseases, and obesity as a predisposition to diabetes are just a few examples of how this edition provides essential pathophysiology information for health professionals.
• All-new sections covering a wide range of new and emerging areas of vital interest to all healthcare professionals. New sections include: Sex and Gender-based Issues in Medicine; Obesity, Diabetes Mellitus, and Metabolic Syndrome; and Consultative Medicine— Plus, a new Part covering cutting-edge topics in research and clinical medicine includes great new chapters on the role of Epigenetics in Health and Disease, Behavioral Strategies to Improve Health, Genomics and Infectious Diseases, Emerging Neuro-Therapeutic Technologies, and Telomere Function in Health and Disease, and Network System Medicine.
• Important and timely new chapters—such as Promoting Good Health, LGBT Health, Systems of Healthcare, Approach to Medical Consultation, Pharmacogenomics, Antimicrobial Resistance, Worldwide Changes in Patterns of Infectious Diseases, Neuromyelitis Optica, and more—offer the very latest, definitive perspectives on must-know topics in medical education and practice.
• Updated clinical guidelines, expert opinions, and treatment approaches from world-renowned editors and authors contribute to the accuracy and immediacy of the text material and present a clear blueprint for optimizing patient outcomes.
• End-of-chapter suggested readings reinforce the text material and provide a robust platform for further study and research.

• Two printed books
• Format 22 x 28 cm
• 3.530 pages printed in full color
• Language English
• Fine hardcover binding plasticized
• 20th Edition, year 2018
• ISBN: 978-1-259-64403-0, 9781259644030
• Authors: Dennis L. Kasper, Anthony S. Fauci, Stephen L. Hauser, Dan L. Longo, J. Larry Jameson and Joseph Loscalzo
• © McGraw-Hill

Part 1: The Profession of Medicine.
1. The Practice of Medicine.
2. Promoting Good Health.
3. Decision-Making in Clinical Medicine.
4. Screening and Prevention of Disease.
5. Health Care Systems in Developed Countries.
6. The Safety and Quality of Health Care.
7. Racial and Ethnic Disparities in Health Care.
8. Ethical Issues in Clinical Medicine.
9. Palliative and End-of-Life Care.

Part 2: Cardinal Manifestations and Presentation of Diseases
Section 1: Pain
10. Pain: Pathophysiology and Management.
11. Chest Discomfort.
12. Abdominal Pain.
13. Headache.
14. Back and Neck Pain.

Section 2: Alterations in Body Temperature
15. Fever.
16. Fever and Rash.
17. Fever of Unknown Origin.

Section 3: Nervous System Dysfunction.
18. Syncope.
19. Dizziness and Vertigo.
20. Fatigue.
21. Neurologic Causes of Weakness and Paralysis.
22. Numbness, Tingling, and Sensory Loss.
23. Gait Disorders, Imbalance and Falls.
24. Confusion and Delirium.
25. Dementia.
26. Aphasia, Memory Loss, Hemispatial Neglect, Frontal Syndromes, and Other Cerebral Disorders.
27. Sleep Disorders

Section 4: Disorders of Eyes, Ears, Nose, and Throat.
28. Disorders of the Eye.
29. Disorders of Smell and Taste.
30. Disorders of Hearing.
31. Sore Throat, Earache, and Upper Respiratory Symptoms.
32. Oral Manifestations of Disease

Section 5: Alterations in Circulatory and Respiratory Functions
33. Dyspnea.
34. Cough.
35. Hemoptysis.
36. Hypoxia and Cyanosis.
37. Edema.
38. Approach to the Patient with a Heart Murmur.
39. Palpitations

Section 6: Alterations in Gastrointestinal Function.
40. Dysphagia.
41. Nausea, Vomiting, and Indigestion.
42. Diarrhea and Constipation.
43. Unintentional Weight Loss.
44. Gastrointestinal Bleeding.
45. Jaundice.
46. Abdominal Swelling and Ascites.

Section 7: Alterations in Renal and Urinary Tract Function.
47. Dysuria, Bladder Pain, and the Interstitial Cystitis/ Bladder Pain Syndrome.
48. Azotemia and Urinary Abnormalities.
49. Fluid and Electrolyte Disturbances.
50. Hypercalcemia and Hypocalcemia.
51. Acidosis and Alkalosis

Section 8: Alterations in the Skin.
52. Approach to the Patient with a Skin Disorder.
53. Eczema, Psoriasis, Cutaneous Infections, Acne, and Other Common Skin Disorders.
54. Skin Manifestations of Internal Disease.
55. Immunologically Mediated Skin Diseases.
56. Cutaneous Drug Reactions.
57. Photosensitivity and Other Reactions to Light.

Section 9: Hematologic Alterations.
58. Interpreting Peripheral Blood Smears.
59. Anemia and Polycythemia.
60. Disorders of Granulocytes and Monocytes.
61. Bleeding and Thrombosis.
62. Enlargement of Lymph Nodes and Spleen.

Part 3: Pharmacology.
63. Principles of Clinical Pharmacology.
64. Pharmacogenomics.

Part 4: Oncology and Hematology.
Section 1: Neoplastic Disorders.
65. Approach to the Patient with Cancer.
66. Prevention and Early Detection of Cancer.
67. Cancer Genetics.
68. Cancer Cell Biology.
69. Principles of Cancer Treatment.
70. Infections in Patients with Cancer.
71. Oncologic Emergencies.
72. Cancer of the Skin.
73. Head and Neck Cancer.
74. Neoplasms of the Lung.
75. Breast Cancer.
76. Upper Gastrointestinal Tract Cancers.
77. Lower Gastrointestinal Cancers.
78. Tumors of the Liver and Biliary Tree.
79. Pancreatic Cancer.
80. Neuroendocrine Tumors of the Gastrointestinal Tract and Pancreas.
81. Renal Cell Carcinoma.
82. Cancer of the Bladder and Urinary Tract.
83. Benign and Malignant Diseases of the Prostate.
84. Testicular Cancer.
85. Gynecologic Malignancies.
86. Primary and Metastatic Tumors of the Nervous System.
87. Soft Tissue and Bone Sarcomas and Bone Metastases.
88. Carcinoma of Unknown Primary.
89. Paraneoplastic Syndromes: Endocrinologic/Hematologic.
90. Paraneoplastic Neurologic Syndromes and Autoimmune Encephalitis.
91. Late Consequences of Cancer and Its Treatment.

Section 2: Hematopoietic Disorders.
92. Hematopoietic Stem Cells.
93. Iron Deficiency and Other Hypoproliferative Anemias.
94. Disorders of Hemoglobin.
95. Megaloblastic Anemias.
96. Hemolytic Anemias.
97. Anemia Due to Acute Blood Loss.
98. Bone Marrow Failure Syndromes Including Aplastic Anemia and Myelodysplasia.
99. Polycythemia Vera and Other Myeloproliferative Neoplasms.
100. Acute Myeloid Leukemia.
101. Chronic Myeloid Leukemia.
102. Acute Lymphoid Leukemia.
103. Chronic Lymphocytic Leukemia.
104. Non-Hodgkin’s Lymphoma.
105. Hodgkin's Lymphoma.
106. Less Common Hematologic Malignancies.
107. Plasma Cell Disorders.
108. Amyloidosis.
109. Transfusion Biology and Therapy.
110. Hematopoietic Cell Transplantation.

Section 3: Disorders of Hemostasis.
111. Disorders of Platelets and Vessel Wall.
112. Coagulation Disorders.
113. Arterial and Venous Thrombosis.
114. Antiplatelet, Anticoagulant, and Fibrinolytic Drugs.

Part 5: Infectious Diseases.
Section 1: Basic Considerations in Infectious Diseases.
115. Approach to the Patient with an Infectious Disease.
116. Molecular Mechanisms of Microbial Pathogenesis.
117. Approach to the Acutely Ill Infected Febrile Patient.
118. Immunization Principles and Vaccine Use.
119. Health Recommendations for International Travel.
120. Climate Change and Infectious Disease.

Section 2: Clinical Syndromes: Community-Acquired Infections.
121. Pneumonia.
122. Lung Abscess.
123 Infective Endocarditis.
124. Infections of the Skin, Muscles, and Soft Tissues.
125. Infectious Arthritis.
126. Osteomyelitis.
127. Intraabdominal Infections and Abscesses.
128. Acute Infectious Diarrheal Diseases and Bacterial Food Poisoning.
129. Clostridium difficile Infection, Including Pseudomembranous Colitis.
130. Urinary Tract Infections, Pyelonephritis, and Prostatitis.
131. Sexually Transmitted Infections: Overview and Clinical Approach.
132. Encephalitis.
133. Acute Meningitis.
134. Chronic and Recurrent Meningitis.
135. Brain Abscess and Empyema.
136. Infectious Complications of Bites.

Section 3: Clinical Syndromes: Health Care-Associated Infections
137. Infections Acquired in Health Care Facilities.
138. Infections in Transplant Recipients.

Section 4: Therapy for Bacterial Diseases.
139. Treatment and Prophylaxis of Bacterial Infections.
140. Bacterial Resistance to Antimicrobial Agents.

Section 5: Diseases Caused by Gram-Positive Bacteria.
141. Pneumococcal Infections.
142. Staphylococcal Infections.
143. Streptococcal Infections.
144. Enterococcal Infections.
145. Diphtheria and Other Corynebacterial Infections.
146. Listeria monocytogenes Infections.
147. Tetanus.
148. Botulism.
149. Gas Gangrene and Other Clostridial Infections.

Section 6: Diseases Caused by Gram-Negative Bacteria.
150. Meningococcal Infections.
151. Gonococcal Infections.
152. Haemophilus and Moraxella Infections.
153. Infections Due to the HACEK Group and Miscellaneous Gram-Negative Bacteria.
154. Legionella Infections.
155. Pertussis and Other Bordetella Infections.
156. Diseases Caused by Gram-Negative Enteric BacilliThomas A. Russo, James R. Johnson
157. Acinetobacter Infections.
158. Helicobacter pylori Infections.
159. Infections Due to Pseudomonas, Burkholderia, and Stenotrophomonas Species.
160. Salmonellosis.
161. Shigellosis.
162. Infections Due to Campylobacter and Related Organisms.
163. Cholera and Other Vibrioses.
164. Brucellosis.
165. Tularemia.
166. Plague and Other Yersinia Infections.
167. Bartonella Infections, Including Cat-Scratch Disease.
168. Donovanosis.

Section 7: Miscellaneous Bacterial Infections.
169. Nocardiosis.
170. Actinomycosis.
171. Whipple’s Disease.
172. Infections Due to Mixed Anaerobic Organisms.

Section 8: Mycobacterial Diseases.
173. Tuberculosis.
174. Leprosy.
175. Nontuberculous Mycobacterial Infections.
176. Antimycobacterial Agents.

Section 9: Spirochetal Diseases
177. Syphilis.
178. Endemic Treponematoses.
179. Leptospirosis.
180. Relapsing Fever.
181. Lyme BorreliosisAllen C. Steere

Section 10: Diseases Caused by Rickettsiae, Mycoplasmas, and Chlamydiae.
182. Rickettsial Diseases.
183. Infections Due to Mycoplasmas.
184. Chlamydial Infections.

Section 11: Viral Diseases: General Considerations.
185. Medical Virology.
186. Antiviral Chemotherapy, Excluding Antiretroviral Drugs.

Section 12: Infections Due to DNA Viruses.
187. Herpes Simplex Virus Infections.
188. Varicella-Zoster Virus Infections.
189. Epstein-Barr Virus Infections, Including Infectious Mononucleosis.
190. Cytomegalovirus and Human Herpesvirus Types 6, 7, and 8.
191. Molluscum Contagiosum, Monkeypox, and Other Poxvirus Infections.
192. Parvovirus Infections.
193. Human Papillomavirus Infections.

Section 13: Infections Due to DNA and RNA Respiratory Viruses.
194. Common Viral Respiratory Infections.
195. Influenza.

Section 14: Infections Due to Human Immunodeficiency Virus and Other Human Retroviruses.
196. The Human Retroviruses.
197. Human Immunodeficiency Virus Disease: AIDS and Related Disorders.

Section 15: Infections Due to RNA Viruses.
198. Viral Gastroenteritis.
199. Enterovirus, Parechovirus, and Reovirus Infections.
200. Measles (Rubeola).
201. Rubella (German Measles).
202. Mumps.
203. Rabies and Other Rhabdovirus Infections.
204. Arthropod-Borne and Rodent-Borne Virus Infections.
205. Ebolavirus and Marburgvirus Infections.

Section 16: Fungal Infections.
206. Diagnosis and Treatment of Fungal Infections.
207. Histoplasmosis.
208. Coccidioidomycosis.
209. Blastomycosis.
210. Cryptococcosis.
211. Candidiasis.
212. Aspergillosis.
213. Mucormycosis.
214. Superficial Mycoses and Less Common Systemic Mycoses.
215. Pneumocystis Infections.

Section 17: Protozoal and Helminthic Infections: General Considerations.
216. Introduction to Parasitic Infections.
217. Agents Used to Treat Parasitic Infections.

Section 18: Protozoal Infections.
218. Amebiasis and Infection with Free-Living Amebae.
219. Malaria.
220. Babesiosis.
221. Leishmaniasis.
222. Chagas Disease and African Trypanosomiasis.
223. Toxoplasma Infections.
224. Protozoal Intestinal Infections and Trichomoniasis.

Section 19: Helminthic Infections.
225. Introduction to Helminthic Infections.
226. Trichinellosis and Other Tissue Nematode Infections.
227. Intestinal Nematode Infections.
228. Filarial and Related Infections.
229. Schistosomiasis and Other Trematode Infections.
230. Cestode Infections.

Part 6: Disorders of the Cardiovascular System.
Section 1: Introduction to Cardiovascular Disorders.
231. Approach to the Patient with Possible Cardiovascular Disease.
232. Basic Biology of the Cardiovascular System.
233. Epidemiology of Cardiovascular Disease.

Section 2: Diagnosis of Cardiovascular Disorders.
234. Physical Examination of the Cardiovascular System.
235. Electrocardiography.
236. Noninvasive Cardiac Imaging: Echocardiography, Nuclear Cardiology, and Magnetic Resonance/Computed Tomography Imaging.
237. Diagnostic Cardiac Catheterization and Coronary Angiography.

Section 3: Disorders of Rhythm.
238. Principles of Electrophysiology.
239. The Bradyarrhythmias: Disorders of the Sinoatrial Node.
240. The Bradyarrhythmias: Disorders of the Atrioventricular Node.
241. Approach to Supraventricular Tachyarrhythmias.
242. Physiologic and Non-physiologic Sinus Tachycardia.
243. Focal Atrial Tachycardia.
244. Paroxysmal Supraventricular Tachycardias.
245. Common Atrial Flutter, Macroreentrant and Multifocal Atrial Tachycardias.
246. Atrial Fibrillation.
247. Approach to Ventricular Arrhythmias.
248. Premature Ventricular Beats, Non-sustained Ventricular Tachycardia, and Idioventricular Rhythm.
249. Sustained Ventricular Tachycardia.
250. Polymorphic Ventricular Tachycardia and Ventricular Fibrillation.
251. Electrical Storm and Incessant VT.

Section 4: Disorders of the Heart.
252. Heart Failure: Pathophysiology and Diagnosis.
253. Heart Failure: Management.
254. Cardiomyopathy and Myocarditis.
255. Cardiac Transplantation and Prolonged Assisted Circulation.
256. Aortic Valve Disease.
257. Aortic Regurgitation.
258. Mitral Stenosis.
259. Mitral Regurgitation.
260. Mitral Valve Prolapse.
261. Tricuspid Valve Disease.
262. Pulmonic Valve Disease.
263. Multiple and Mixed Valvular Heart Disease.
264. Congenital Heart Disease in the Adult.
265. Pericardial Disease.
266. Atrial Myxoma and Other Cardiac Tumors.

Section 5: Coronary and Peripheral Vascular Disease.
267. Ischemic Heart Disease.
268. Non-ST-Segment Elevation Acute Coronary Syndrome (Non-ST-Segment Elevation Myocardial Infarction and Unstable Angina).
269. ST-Segment Elevation Myocardial Infarction.
270. Percutaneous Coronary Interventions and Other Interventional Procedures.
271. Hypertensive Vascular Disease.
272. Renovascular Disease.
273. Deep Venous Thrombosis and Pulmonary Thromboembolism.
274. Diseases of the Aorta.
275. Arterial Diseases of the Extremities.
276. Chronic Venous Disease and Lymphedema.
277. Pulmonary Hypertension.

Part 7: Disorders of the Respiratory System.
Section 1: Diagnosis of Respiratory Disorders
278. Approach to the Patient with Disease of the Respiratory System.
279. Disturbances of Respiratory Function.
280. Diagnostic Procedures in Respiratory Disease.

Section 2: Diseases of the Respiratory System.
281. Asthma.
282. Hypersensitivity Pneumonitis and Pulmonary Infiltrates with Eosinophilia.